Professor   

 

 

 

Bartosz Andrzej Grzybowski


Distinguished Professor, Department of Chemistry, UNIST

Director, Center for Algorithmic and Robotized Synthesis (CARS), 

                    Institute for Basic Science 

 

 

Grzybowski
CV

 

 

 

RESEARCH SUMMARY

 

 

Grzybowski group has pioneered applications of artificial intelligence and network theory to synthetic chemistry - this work has given rise to the creation of the Chematica/Synthia platform for computerized retrosynthesis of complex molecules, including natural products (Nature 2020a), as well as the Allchemy software for the discovery of new synthetic methodologies and new functional molecules (Science 2020, Nature 2022).  Our current interests in this arena focus on computer-driven discovery of new reactions and catalysts and also on robotized systems in which chemical AI controls and optimizes actual experiments. We are also very active in a quest to develop "smart" systems that, in one vessel, perform multiple chemical reactions and/or processes - for instance, multistep synthetic cascades (Nature 2020b) or processes (Nature 2022c). We are also working at the intersection of molecular chemistry with nanotechnology to develop platforms for selective catalysis (JACS 2021) as well as therapeutic warheads for selective cancer intervention (Nature Nanotech 2020). Overall, we are a diverse crowd of chemists, physicists, and biologists and we pursue research that we think is paradigm-shifting and/or addresses important societal needs. Our group is a place to consider if you are passionate about science and would like to make chemistry a truly high-tech enterprise!

 

EDUCATION AND ACADEMIC EXPERIENCE

 

 

6/1995

B.S., Chemistry, Yale University, New Haven, CT

 

6/1995

M.Sc., Chemistry, Yale University, New Haven, CT

 

11/2000

Ph.D., Chemistry, Harvard University, Cambridge, MA

 

10/2000-7/2001

Postdoctoral Fellow, Harvard University

 

7/2001-8/2003

Director of Research, Vitae Pharmaceuticals and Associate of the Department of Chemistry and Chemical Biology, Harvard University

 

9/2003-8/2007

Assistant Professor, Northwestern University, Department of Chemical and Biological Engineering and Department of Chemistry

 

9/2007-8/2009

Associate Professor, Northwestern University, Department of Chemical and Biological Engineering and Department of Chemistry

 

9/2009-12/2014

Director of the DoE Energy Frontier Research Center (Non-Equilibrium Energy Research Center, Northwestern University)

 

9/2009-12/2014

Full Professor, Kenneth Burgess Chair in Physical Chemistry and Chemical Systems Engineering, 

Department of Chemical and Biological Engineering and Department of Chemistry

 

9/2014-present 

Professor, Polish Academy of Sciences

 

12/2014-present 

Distinguished Professor of Chemistry, UNIST

 

7/2015-present

5/2023-12/2023

1/2024-present

Group Leader, IBS Center for Soft and Living Matter @ UNIST

Acting Director, IBS Center for Soft and Living Matter @ UNIST

Director, IBS Center for Algorithmic and Robotized Synthesis @ UNIST

  

HONORS AND AWARDS

 

 

Arthur Fleischer Award for Outstanding Performance in Chemistry, Yale University (1995)

 

Honoris in Chimia, Yale University (1995)

 

Summa cum Laude, Yale University (1995)

 

Camille and Henry Dreyfus New Faculty Award (2003)

 

National Science Foundation CAREER Award (2006)

 

3M Non-Tenured Faculty Award (2006)

 

Pew Scholar in the Biomedical Sciences (2006)

 

American Chemical Society Division of Colloid and Surface Chemistry Unilever Award (2006)

 

Sloan Fellowship (2007)

 

Camille Dreyfus Teacher-Scholar Award (2007)

 

G.Kanig Award for Innovation (Verband für Polymerforschung, Germany) (2008)

 

Soft Matter Lecturership (Royal Society of Chemistry, UK) (2010)

 

Saville Lecturership (Princeton University) (2010)

 

Crano Distinguished Lectureship (American Chemical Society, Akron Section) (2010)

 

American Institute of Chemical Engineers NSEF Young Investigator Award (2010)

 

Centennial Year of Chemistry Distinguished Lecture (Wroclaw University, Poland) (2011)

 

Excellence in Nanoscience Lectureship (EPFL, Switzerland) (2012) 

 

MESA Institute Annual Lecture (University of Twente, the Netherlands) (2012)

 

ISIS Distinguished Lectureship (University of Strasbourg, France) (2012)

 

Nanoscience Prize (International Society for Nanoscale Science, Computation and Engineering) (2013)

 

The Givaudan Lecture and the Bristol Synthesis Meeting (2014)

 

Fellow of the Royal Society of Chemistry (2015)

 

The Feynman Prize in Nanotechnology (2016)

 

WuXi Distinguished Lecturer (Shanghai, China) (2018)

 

Sendzimir Honorary Medal (Society of Innovators, Poland) (2019)

 

25th Solvay Conference on Chemistry (Brussels, Belgium) (2019)

 

NIH NCATS "Aspire" Award (National Institutes of Health, NIH, Washington, USA) (2019)

 

Elected Member of the Societas Scientarum Varsaviensis (Towarzystwo Naukowe Warszawskie) (2020)

 

AbbVie Discovery 2021 Platform Chemistry Technology Seminar (2021)

Grand Academic Award (Academic Affairs Team, UNIST) (2020)

FNP Prize (Foundation for Polish Science) (2022)

Bowei Research Conference Lecture (Kending, Taiwan) (2023)

Solvay Workshop on Chemistry (Brussels, Belgium) (2023)

IUPAC Plenary Lecture (The Hague, The Netherlands) (2023)

 

RESEARCH AREAS

 

 

Computerized synthesis and artificial intelligence, AI, applied to organic chemistry

Discovery of new reactions and of new drugs

AI for chemical waste management

Complex chemical networks and catalytic systems

Self-assembly in non-equilibrium regimes

Energy storage

Nanomaterials for catalysis and nanomedicine

 

HIGHLIGHTS OF SCIENTIFIC CONTRIBUTIONS

 

 

Grzybowski and his team pioneered research on non-equilibrium self-assembly processes in chemical systems (Nature 2000, Science 2002a, Science 2002b, Nature 2018, Nature 2020a, Nature 2020b). They were the first ones to describe nanoscale self-assembly based on electrostatic interactions (Science 2006), and first ones to demonstrate all-nanoparticle electronics (Nature Nanotechnology 2011, 2016, Nature Materials 2012). Grzybowski's team discovered several fundamental phenomena at small scales (e.g., plastic-metals, Science 2007; inverse photoconductors, Nature 2009) and is recognized as being the pioneers of reaction-diffusion chemical systems operating in the nano- and microscopic regimes (reviewed in Angew. Chem. 2010 and also in Grzybowski's textbook on the subject). In 2011, the group solved perhaps the oldest scientific question - originally posed by Thales of Miletus  - as to how and why materials charge upon contact with one another (Science 2011, Science 2013). In 2013, they have demonstrated magnetic traps that unlike their optical counterparts can manipulate nanoscopic objects, both magnetic and non-magnetic (Nature 2013).

Grzybowski's most impactful discoveries are in the area of computer-planned organic synthesis and AI for reaction and drug discovery. The Grzybowski group discovered and quantified the general laws governing the Network of Organic Synthesis (Nature Chemistry 2009), and created Chematica, the "chemical brain" for the planning of organic syntheses (Angew. Chem. 2012a, 2012b, 2012c, 2016, Chem 2018,2019, 2020). In 2020, they demonstrated how computers can plan syntheses to complex natural products (Nature 2020) and how they can discover new prebiotic syntheses (Science 2020). 

Grzybowski has a strong track record of research commercialization. The companies he started has achieved a valuation of close to $1 billion. He also advises pharma industry (e.g., Merck) and has managed a portfolio of research grants (from US, Korean and Polish governments totaling >$40 million).

Grzybowski is an author of over 280 articles cited close ca. 20,000 times (Web of Science). Over the years, he received several awards including NSF CAREER Award, Pew Scholar in the Biomedical Sciences, American Institute of Chemical Engineers NSEF Young Investigator Award, ACS Unilever Award, Sloan Fellowship, Dreyfus Teacher-Scholar Award, Nanoscience Prize,  2016 Feynman Prize, 2020 UNIST's Grand Academic Award, and 2022 FNP Prize. 


 

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